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Cell Population Analyses During Skin Carcinogenesis
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患有出生缺陷的儿童和青少年中癌的风险
Jeremy M Schraw1, Ji Yun Tark2, Tania A Desrosiers3
1Division of Hematology/Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX USA.
Cancer epidemiology
|January 23, 2025
概括
患有出生缺陷的儿童,包括非综合征异常和遗传综合征,面临患儿癌症,特别是肝细胞和类型的风险增加. 这突显了先天性异常与儿童癌症风险之间的显著联系.
科学领域:
- 儿科瘤学 儿科瘤学
- 出生缺陷的研究研究.
- 癌症流行病学癌症流行病学
背景情况:
- 众所周知,出生缺陷与儿童癌症有关.
- 然而,先天性异常和罕见的儿科癌症之间的具体关系仍然不太清楚.
- 这项研究解决了这一知识差距,通过调查出生缺陷儿童中各种癌症的风险.
研究的目的:
- 调查主要非综合征异常或染色体/遗传综合征与患任何癌症的风险之间的联系,直到18岁.
- 专门检查出生缺陷的儿童甲状腺,肝细胞和癌的风险.
- 量化这些癌症的增加危险比率 (HR) 和置信区间 (CI).
主要方法:
- 使用了考克斯的比例危险回归分析.
- 包括一个大型的注册表链接研究,涉及9个州 (1990-2018) 超过2100万名儿童.
- 与未受影响儿童相比,患有非综合征异常 (n=641,827) 和综合征 (n=49,619) 的儿童的癌症发病率.
主要成果:
- 在患有非综合征异常 (HR: 1.7,CI: 1.2-2.4) 和综合征 (HR: 4.7,CI: 2.3-9.5) 的儿童中,整体癌症风险较高.
- 在这两组中,肝细胞癌的风险显著增加 (HR:分别为4.6和8.0).
- 在患有结核硬化症的儿童中,癌风险明显增加 (HR:59.6). 甲状腺癌没有显示任何关联.
结论:
- 出生缺陷,特别是非综合征异常和遗传综合征,与儿科肝细胞和癌的风险增加有关.
- 先天性异常是特定类型的儿童癌症的重要风险因素.
- 这些发现强调了在儿童癌症风险评估中考虑先天性缺陷史的重要性.
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