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Updated: May 31, 2025

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在结直肠癌的发展中,Fusobacterium nucleatum调节了Wnt/β-catenin通路
Tanushree Mondal1, Deepanjan Chattopadhyay1, Paromita Saha Mondal1
1Department of Molecular Biology and Biotechnology, University of Kalyani, Kalyani 741235, Nadia, West Bengal, India.
International journal of biological macromolecules
|January 23, 2025
概括
当Wnt/β-catenin通路失调时,会导致结直肠癌 (CRC) 的进展. Fusobacterium nucleatum利用这种途径,为CRC治疗提供了一个潜在的治疗点.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 分子生物学分子生物学
背景情况:
- Wnt/β-catenin信号通路对于细胞平衡至关重要,但其异常调节驱动瘤发生,特别是在结肠直肠癌 (CRC).
- 结肠直肠癌 (CRC) 是全球普遍存在的胃肠道恶性瘤,其特征是Wnt/β-catenin通路放松调节.
- 人类开始生长的微生物,特别是Fusobacterium nucleatum,越来越多地与致癌和CRC进展有关.
研究的目的:
- 阐明Fusobacterium nucleatum在CRC发育中调节Wnt/β-catenin通路的机制.
- 探索向Wnt/β-catenin通路的潜力,以便在Fusobacterium nucleatum阳性CRC中进行治疗干预.
主要方法:
- 关于Wnt/β-catenin信号传递,CRC病变以及Fusobacterium nucleatum的作用的现有文献的综述.
- 对Fusobacterium nucleatum和宿主细胞之间的分子相互作用进行分析,重点关注E-cadherin和Wnt通路激活.
主要成果:
- 菌核素利用其粘附物与E-cadherin相互作用,启动感染并可能激活Wnt/β-catenin通路.
- 核菌对Wnt/β-catenin通路的失调有助于CRC恶性瘤,包括细胞迁移,血管生成和化学抵抗.
结论:
- Fusobacterium nucleatum通过操纵Wnt/β-catenin信号通路,在CRC的发展和进展中发挥着重要作用.
- 针对Wnt/β-catenin通路为F.核阳性CRC提供了一个有前途的治疗策略.
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