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Updated: May 31, 2025

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

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Published on: March 9, 2018

甲基化物 A-D,是来自阿斯伯吉卢斯化物 (Aspergillus aculeatus) 的第二种具有免疫抑制活性的17-nor化物二甲基化物

Fei Liu¹, Qin Li², Yongqi Li²

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China; Department of Radiation Medicine and Environment Medicine, China Institute for Radiation Protection, Taiyuan, 030006, People's Republic of China.

|January 23, 2025

概括

十个新的修改后的fusiococcane diterpenoids,aculeanoids A-J,被发现从阿斯伯吉洛斯aculeatus. 化合物6,7和10显示出显著的免疫抑制活性,为自身免疫性疾病和器官移植排斥提供了潜在的治疗方法.

科学领域:

自然产品化学自然产品化学
有机化学有机化学
免疫学免疫学免疫学

背景情况:

阿斯珀吉勒斯菌种是众所周知的多种生物活性二次代谢物的来源.
富西科卡纳类型的二类物质代表了一类具有多种生物活性的自然产品.
研究微生物代谢物对于发现新型治疗剂至关重要.

研究的目的:

从真菌Aspergillus aculeatus中分离和描述新的二次代谢产物.
为了阐明隔离化合物的结构和绝对配置.
评估已识别的化合物的免疫抑制潜力.

主要方法:

综合光谱分析 (NMR,MS) 用于结构阐明.
用DP4+分析,Mo2(OAc) 4诱导的ECD和ECD计算来确定绝对配置.
在体外测试中评估了对T和B细胞增殖的免疫抑制活性.

主要成果:

鉴定出了10种修饰后的状类型的二类生物,被命名为A-J (1-10) 的类生物.
化合物 1-4 代表了17-nor fusicoccane diterpenoids的一个罕见的子类.
化合物6,7和10对T和B细胞增殖表现出显著的免疫抑制作用.

结论:

这项研究扩大了fusiococcane diterpenoids的化学多样性.
6,7和10的阿库莱诺伊德表现出有希望的免疫抑制性质.
这些发现表明,在管理自身免疫性疾病和器官移植结果方面的潜在治疗应用.

关键词:

亚斯伯吉拉斯 (Aspergillus aculeatus) 是一种植物.富西科卡尼斯 (Fusicoccanes) 是一个古老的生物.免疫抑制活动免疫抑制活动诺尔-迪特尔类化合物这种植物属于Trichocomaceae.

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