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Updated: May 31, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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线粒体关联的内细胞网膜的MFN2介导下降有助于苏尼蒂尼布诱导的内皮功能障碍和高血压

Yao Qu1, Zhi-Xue Liu2, Xiao-Xu Zheng2

  • 1Department of Cardiology, Harbin Medical University Cancer Hospital, NHC Key Laboratory of Cell Transplantation, Department of Cardiology, Central Laboratory, The First Affiliated Hospital of Harbin Medical University, Institute of Metabolic Disease, Heilongjiang Academy of Medical Sciences, Heilongjiang Key Laboratory for Metabolic Disorder & Cancer Related Cardiovascular Diseases, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin, China; Center for Molecular and Translational Medicine, Georgia State University, Atlanta, USA.

Journal of molecular and cellular cardiology
|January 23, 2025
PubMed
概括

像苏尼蒂尼布这样的氨酸激酶抑制剂通过损害内皮细胞线粒体和减少与线粒体相关的内细胞网膜 (MAMs) 来引起高血压. 恢复MAMs功能可能是对抗这种副作用的治疗策略.

关键词:
脑内皮质 (Endothelium) 是一个内皮质.在高血压的高血压.IP(3) R1 一个R1一个一个MAM就是MAM.在MFN2中,MFN2是MFN2.苏尼蒂尼布 (sunitinib) 是一种

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