与代谢功能障碍相关的脂肪性肝病和心血管系统
Antonis A Manolis1, Theodora A Manolis2, Apostolos Vouliotis3
1Department of Medicine, Elpis General Hospital, Athens, Greece.
Trends in cardiovascular medicine
|January 23, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 是与心血管疾病相关的日益严重的健康问题. 早期诊断和管理MASLD,包括改变生活方式和向治疗,对于改善患者的治疗结果至关重要.
科学领域:
- 肝病学和代谢疾病
- 心血管医学 心血管医学
- 临床药理学 临床药理学
背景情况:
- 代谢功能障碍相关的脂肪性肝病 (MASLD),以前是非酒精性脂肪性肝病,影响25-30%的成年人,高达70%的糖尿病患者.
- MASLD是一种多系统性疾病,增加了2型糖尿病,心血管疾病,慢性病和肝细胞癌的风险.
- 心血管事件是MASLD患者的主要死亡原因,这强调了肝脏和代谢健康之间的联系.
研究的目的:
- 审查MASLD的流行病学,诊断,并发病症和管理策略.
- 要突出MASLD与动脉样硬化心血管疾病之间的显著联系.
- 讨论MASLD当前和新兴的治疗方案,包括生活方式修改和药物治疗.
主要方法:
- 对有关MASLD患病率,风险因素和临床结果的文献进行系统审查.
- 对诊断标准的分析,包括肝肥胖症和心脏代谢风险因素.
- 评估管理策略,包括生活方式的改变,并发症控制和药物干预措施.
主要成果:
- MASLD非常普遍,特别是在糖尿病人群中,并且与诸如肥胖,高脂血症和高血压等众多代谢并发症有关.
- 心血管疾病是导致死亡的首要原因,强调了综合管理的关键需要.
- 生活方式的修改,他类药物和像resmetirom这样的特定药物在管理MASLD及其并发症方面显示出希望.
结论:
- MASLD是一个重要的公共卫生问题,具有深刻的心血管影响.
- 包括生活方式变化,并发病率优化和向治疗在内的综合管理对于改善预后至关重要.
- 对MASLD向药物治疗的进一步研究是有必要的,特别是在非脊髓炎的疾病阶段.
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