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发现了伊塔科纳酸和衍生品的口服产药

Chae Bin Lee, Ivan Šnajdr1, Lukáš Tenora1

  • 1Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic v.v.i., Prague 160 00, Czech Republic.

Journal of medicinal chemistry
|January 23, 2025
PubMed
概括

新的口服可用的伊塔康酸原药克服了细胞透性差. 基于POC的衍生品P2和P13通过提高itaconate的生物可用性,显示出治疗炎症性皮肤和全身疾病的前景.

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