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Updated: May 31, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

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用双人内源性逆转录病毒进行分层系统,用于预测转移性清细胞癌中免疫治疗的疗效

Xiaofan Lu1, Yann-Alexandre Vano2,3, Xiaoping Su4

  • 1Department of Cancer and Functional Genomics, Institute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS/INSERM/UNISTRA, Illkirch-Graffenstaden, France.

Journal for immunotherapy of cancer
|January 23, 2025
PubMed
概括

一种新的双内源逆转录病毒 (ERV) 风险模型预测了转移性清细胞脏细胞癌 (ccRCC) 免疫检查点抑制剂 (ICI) 反应. 这种ERV分层系统改进了精密瘤学的现有模型.

关键词:
生物标志物生物标志物免疫检查点抑制剂 免疫检查点抑制剂免疫治疗是一种免疫疗法.癌 癌 癌 癌 癌瘤微环境 - - 瘤微环境

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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