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酸寡合表面活性剂的抗模具活性
Zeyu Zhao1,2, Bin Liu3, Ziqi Zhang1,2
1CAS Key Laboratory of Colloid, Interface, and Chemical Thermodynamics, Beijing National Laboratory for Molecular Sciences Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Langmuir : the ACS journal of surfaces and colloids
|January 23, 2025
概括
带有因胺键的阴离四级表面活性剂显示出强大的杀菌活性. 它们的有效性取决于结构和表面,提供广泛的抗微生物潜力,耐药性降低.
科学领域:
- 材料科学 材料科学 材料科学
- 微生物学 微生物学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 菌构成重大威胁,但与细菌相比,缺乏研究.
- 增加微生物耐药性需要新的抗菌剂.
- 了解表面活性剂的结构-活性关系对于开发有效的抗微生物药物至关重要.
研究的目的:
- 为了评估小分子阴离子四级表面活性剂的抗效果.
- 为了研究 imine 键和寡合化程度对表面活性剂活性的影响.
- 探索这些表面活性剂作为具有低抗性潜力的宽谱抗菌剂的潜力.
主要方法:
- 合成和表征有或没有胺基键的寡合子阴离子四级表面活性剂.
- 对四种常见的菌物种 (A. niger,T. viride,C. globosum,P. funiculosum) 最低杀菌度 (MFC) 的确定.
- 评估表面活性剂在溶液和织物表面的性能.
主要成果:
- 具有伊胺键的表面活性剂在溶液中表现出比没有这种键的表面活性剂更强的抗活性.
- 随着溶液中的寡合化程度的增加,由于聚合物形成,抗活性下降.
- 具有较高的寡合化度的表面活性剂由于吸附度增加,在织物表面表现更好.
- 以胺为基础的表面活性剂显示出可逆性质,可能减少耐药性发展.
结论:
- 动态共价伊胺键增强四级表面活性剂在溶液中的抗效力.
- 寡合化程度极大地影响表面活性剂的性能,最佳活性在溶液和表面应用之间有所不同.
- 胺基键的可逆性质为开发具有抗药性潜力降低的抗菌剂提供了一种策略.
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