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Updated: Jul 11, 2026

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
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A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

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VCP下游代谢物甘-3-酸盐 (G3P) 抑制CD8+T细胞在HCC微环境中的功能

Cheng Cheng1,2,3, Qingrui Zha1,2,3, Linmao Sun1,2,3

  • 1Department of Hepatobiliary Surgery, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.

Signal transduction and targeted therapy
|January 23, 2025
PubMed
概括

含有瓦洛辛的蛋白质 (VCP) 通过稳定GPD1L,损害肝癌中CD8+T细胞,导致T细胞功能障碍. 将抗PD1疗法向VCP显示为增强抗瘤免疫力的有希望.

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