治疗高级上腺皮层癌的儿童的营养支持
Tarek M Zaghloul1,2, Luca Pio3, Ayatullah G Mostafa4,5
1Department of Surgery, St. Jude Children's Research Hospital, MS 133, 262 Danny Thomas Place, Memphis, TN, 38105, USA. tarekmzaghloul@gmail.com.
Pediatric surgery international
|January 23, 2025
概括
患有晚期上腺皮质癌 (ACC) 的儿科患者由于治疗毒性,经常需要营养支持. 患有ACC的年幼儿童在治疗期间更可能需要补充营养.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症 营养 癌症 营养
- 医疗恶性病的治疗方法
背景情况:
- 皮上腺癌 (ACC) 是一种罕见且具有攻击性的儿科癌症.
- 晚期ACC的治疗包括手术和化疗 (cisplatin,etoposide,doxorubicin,mitotane).
- 对ACC的化疗会引起显著的胃肠道毒性,通常会损害口服摄入量,并需要营养支持.
研究的目的:
- 评估在患有晚期ACC的儿科患者中使用营养补充剂的频率.
- 确定与此种人群需要营养支持相关的因素.
主要方法:
- 在2012年至2022年期间接受治疗的儿童ACC患者的回顾性观察研究.
- 审查了患者的人口统计,治疗方案和肠道或肠周营养的使用情况.
- 分析了口服不耐受和减肥的数据.
主要成果:
- 在11名晚期ACC患者中,54.5%需要补充营养 (肠道和肠周).
- 所有需要营养支持的患者都经历了口服不耐受和显著的体重减轻 (平均13.8%).
- 年轻的患者 (平均年龄为4.45岁) 与老年患者相比,更有可能需要营养支持.
结论:
- 大多数患有IV期ACC的儿科患者在治疗期间需要营养支持.
- 患有ACC的年幼儿童似乎更有可能需要营养干预.
- 积极考虑输送管的位置可以防止治疗延迟.
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