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Updated: May 31, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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系统性IFN-I与局部TLR7/8激动剂相结合,通过c-Jun依赖IL-12表达在树突细胞中促进远程瘤抑制

Martina Sanlorenzo1, Philipp Novoszel1, Igor Vujic2

  • 1Center for Cancer Research, Medical University of Vienna, Comprehensive Cancer Center, Vienna, Austria.

Nature cancer
|January 23, 2025
PubMed
概括

托尔类受体7/8激动剂伊米基莫德 (IMQ) 通过激活树突细胞 (DCs) 有效地治疗瘤和转移. 系统和局部IMQ,结合干扰素I和PD-1阻断,增强抗瘤免疫力和记忆反应.

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