在结肠直肠癌放射治疗中PI3K/AKT/mTOR向:系统性审查
S N Mousavikia1,2, L Darvish3,4, A A Firouzjaei5
1Medical Physics Research Center, Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Journal of gastrointestinal cancer
|January 23, 2025
概括
针对PI3K/AKT/mTOR通路可以克服结直肠癌 (CRC) 中的放射电阻. 将途径抑制剂与放射治疗结合起来,可以提高治疗效率,改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 放射电阻显著限制了放射治疗在结直肠癌 (CRC) 治疗中的有效性.
- PI3K/AKT/mTOR信号通路与CRC进展和放射电阻的发展有关.
- 针对PI3K/AKT/mTOR途径是一个潜在的策略,可以提高瘤治疗结果.
研究的目的:
- 系统地审查PI3K/AKT/mTOR通路抑制剂对改善结直肠癌放射治疗疗效的影响.
- 评估涉及PI3K/AKT/mTOR抑制剂和放射治疗治疗CRC的组合疗法的潜力.
主要方法:
- 在主要的科学数据库 (Scopus,PubMed,Web of Science,Embase,Medline) 进行系统的文献搜索.
- 包括研究PI3K/AKT/mTOR途径抑制剂与结合结直肠癌放射治疗的研究.
- 对临床前和临床试验数据的分析.
主要成果:
- 关于PI3K/AKT/mTOR抑制剂和放射治疗的32篇文章 (27篇临床前,5篇临床试验) 的综述.
- 组合疗法表明瘤存活率降低,诱导细胞亡和细胞循环停止,增强辐射敏感性.
- 在接受组合治疗的结直肠癌患者中观察到有利的治疗结果,尽管研究有限.
结论:
- PI3K/AKT/mTOR通路对于结直肠癌细胞生存至关重要.
- 抑制这种途径可以增强放射治疗的疗效.
- 这些发现支持PI3K/AKT/mTOR抑制剂在CRC治疗中的进一步研究和临床应用.
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