结直肠癌手术后的高输出口腔 - 低前切除综合征的危险因素?
Xuena Zhang1, Qingyu Meng2, Jianna Du1
1Department of Nursing, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050000, China.
BMC gastroenterology
|January 24, 2025
概括
高输出口腔 (HOS) 在直肠癌患者中显著增加主要前下切除综合征 (LARS) 的风险. 管理HOS可能有助于减少LARS在口腔关闭后.
科学领域:
- 结肠直肠外科手术是什么意思
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 低前切除综合征 (LARS) 是直肠癌手术后的一个常见并发症.
- 高输出口腔 (HOS) 对LARS发展的影响尚不清楚.
研究的目的:
- 在直肠癌患者中研究高输出口腔 (HOS) 和主要前下切除综合征 (LARS) 之间的关联.
- 确定这种关联更明显的临床子组.
主要方法:
- 对653名经过预防性静脉切除术逆转的直肠癌患者进行了回顾性分析.
- 根据静脉口腔输出,患者被分为HOS和非HOS组.
- 用多因素物流回归和子组分析来评估相关性.
主要成果:
- 在8.1%的患者中观察到高输出口腔 (HOS),在12.4%的患者中观察到主要LARS.
- HOS与大LARS风险增加210% (OR:3.10;P=0.001) 显著相关.
- 这种关联在老年患者,没有高血压的患者,N0-N1分期和化疗后的患者中更为强烈.
结论:
- 高输出口腔 (HOS) 是直肠癌手术后LARS的主要风险因素.
- 针对性地管理HOS可能对减轻LARS至关重要.
- 对特定临床子组进行进一步研究是有必要的.
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