来自各种来源的食蛋白对短期食物摄入量和肠道激素分泌有不同的影响
Léa Fleury1, Sandy Theysgeur1, Thomas Trachet1
1Université de Lille, UMRT 1158 BioEcoAgro, F-59000 Lille, France.
Food research international (Ottawa, Ont.)
|January 24, 2025
概括
饮食蛋白质来源显著影响能量平衡和腹感. 乳清,豆类和质蛋白在调节食物摄入量和荷尔蒙分泌方面表现最有前途.
科学领域:
- 营养科学 营养科学
- 代谢调节 代谢调节 代谢调节
- 胃肠病学 胃肠病学
背景情况:
- 蛋白质对能量恒温至关重要,影响短期和长期的能量平衡.
- 现有的研究强调了蛋白质在通过肠道荷尔蒙分泌来调节食物摄入和腹的作用,但比较不同蛋白质来源的研究是有限的.
- 了解蛋白质质量和来源的影响对于有效的饮食策略至关重要.
研究的目的:
- 为了比较不同蛋白质来源对Wistar大鼠短期食物摄入量和能量平衡的影响.
- 为了研究这些蛋白质在体外消化后对肠道激素分泌 (GLP-1和CCK) 的影响.
- 阐明蛋白质起源,消化能力,激素分泌和腹感之间的关系.
主要方法:
- 在体内使用Wistar大鼠在代谢中的研究,以评估短期的食物摄入量和呼吸交换比率.
- 在体外静态INFOGEST消化协议以模拟各种蛋白质来源的胃肠道消化.
- 用于测量消化蛋白对肠道激素分泌的影响的STC-1细胞系.
主要成果:
- 在测试蛋白质中观察到短期食物摄入量和呼吸系统交换率的显著差异.
- 蛋白质消化调节了类似葡萄糖-1 (GLP-1) 和胆囊托基宁 (CCK) 的分泌.
- 乳清蛋白,豆蛋白和质蛋白在调节食物摄入量和激素分泌上表现出最显著的影响.
结论:
- 饮食中的蛋白质来源通过影响短期的食物摄入量和腹感,在调节能量恒温中发挥着至关重要的作用.
- 观察到的效应与肠道激素分泌的调节密切相关,这种调节因蛋白质类型和来源而异.
- 蛋白质消化率的变化及其随后对激素释放的影响解释了腹感的差异,强调了蛋白质来源在饮食调节食欲方面的重要性.
更多相关视频
09:16Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells
Published on: April 20, 2017
15.5K
07:05Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
Published on: May 12, 2019
5.8K
相关概念视频
Regulation of Food Intake
182
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
182
Hormonal Regulation
43.1K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.1K
Proteins: Dietary Sources and Requirements
378
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
378
Regulation of the Digestive System
402
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
The effectors in this regulation system are glands and smooth muscles. Activation of...
402
Hormones Secreted by the Stomach
331
Enteroendocrine cells, accounting for only 1% of stomach epithelial cells, play a significant role in digestion and are classified by their digestive hormone secretions.
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
331
Protein Digestion
102.5K
Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
102.5K
