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Updated: May 31, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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工程化 ipilimumab 变种可以结合人类和小鼠 CTLA-4 .

Brett Robison1, S J Diong1, Anusha Kumar1

  • 1Discovery Biotherapeutics, Bristol Myers Squibb, Redwood City, CA, USA.

mAbs
|January 24, 2025
PubMed
概括

为癌症免疫疗法开发更好的小鼠模型至关重要. 这项研究设计了一种抗体来结合人类和小鼠CTLA-4,提高了临床前癌症研究的可翻译性.

关键词:
抗体工程是一种抗体工程.在 CTLA-4 中.免疫检查点是一个检查点.菌体显示器可以显示菌体.种类交叉反应性 种类交叉反应性酵母显示器可以显示酵母.

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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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