洞察COVID相关的粘性菌根症:一项前性研究
Avinash-Shekhar Jaiswal1, Aanchal Kakkar2, Kavneet Kaur2
1Department of Otorhinolaryngology and Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Iranian journal of otorhinolaryngology
|January 24, 2025
概括
在COVID-19相关的粘性菌根症患者中TMPRSS2受体的升高可能解释了敏感性增加. ACE2受体表达保持不变,这表明TMPRSS2在这种共感染中起着关键作用.
科学领域:
- 传染性疾病 传染性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 病毒学 病毒学
背景情况:
- 在COVID-19大流行期间,犀牛轨道脑粘膜病例急剧增加.
- 无论是COVID-19还是粘膜菌病,都将鼻腔粘膜作为入口点,这促使人们对共享的受体作用进行了调查.
- 了解这些分子相互作用对于管理共同感染至关重要.
研究的目的:
- 为了比较ACE2和TMPRSS2受体在鼻腔和鼻组织中的表达.
- 分析COVID-19相关性粘膜瘤 (CAM),COVID-19阴性粘膜瘤 (CNM) 和健康对照患者的受体表达.
主要方法:
- 一项前性研究,涉及接受CAM,CNM和健康个体手术治疗的患者.
- 免疫组织化学用于检测ACE2和TMPRSS2受体在鼻组织中的存在.
- 在三个研究小组中对受体水平的统计比较.
主要成果:
- ACE2受体的阳性仅在顶尖毛囊中观察到,群体之间没有显著差异 (p=0.6).
- 在细胞质,细胞核,表皮和下腺体中发现了TMPRSS2受体.
- 与CNM (p=0.009) 和健康个体 (p=0.002) 相比,CAM患者的TMPRSS2表达显著更高.
结论:
- 在COVID-19相关的粘膜菌症患者中,TMPRSS2受体表达升高.
- 在不同组之间,ACE2受体表达没有显著变化.
- 升高的TMPRSS2可能导致对SARS-CoV-2和随后的Mucorales联合感染的易感性增加.
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