相关实验视频

Updated: May 31, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

增殖性淋巴结膜炎与单克隆性免疫球蛋白沉积物的血液-脏概况

Joseph Johny¹, Elenjickal Elias John¹, Sanjeet Roy²

¹Departments of Nephrology, Christian Medical College Vellore, Ranipet Campus, Ranipet, India.

Indian journal of nephrology

|January 24, 2025

概括

具有单克隆免疫球蛋白沉积 (PGNMID) 的增殖性血球膜炎是罕见的. 循环单克隆免疫球蛋白,轻链限制和治疗类型无法预测PGNMID患者的脏结果.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

具有单克隆免疫球蛋白沉积 (PGNMID) 的增殖性血球炎是一种罕见的病.
它被归类为具有性意义的单克隆性胃病变.
循环单克隆免疫球蛋白 (MIg) 和治疗对结局的临床影响尚不清楚.

研究的目的:

调查MIg,轻链限制,组织病理学和治疗对PGNMID中结局的临床影响.
确定影响PGNMID患者结局的因素.

主要方法:

在2013年至2020年期间诊断出16名PGNMID患者的回顾性分析.
从电子医疗记录中收集的数据,包括血清/尿液电泳,免疫固定电泳 (IFE),自由光链 (FLC) 试验,脏活检和骨髓活检.

主要成果:

主要的光显微镜图案是43.7%的患者患有膜增殖性球膜炎 (MPGN).
循环MIg仅在25%的患者中被检测到.
患有循环MIg的患者功能恶化,蛋白尿尿增加.
38%的患者在3个月的中位数内进展到功能衰竭.

结论:

PGNMID是一种罕见的疾病,活检发生率为0.1%.
循环MIg,轻链限制和治疗类型没有预测脏结果.
尽管最初的蛋白尿,MPGN模式与良好的结局有关.

关键词:

电泳术是一种电泳术.淋巴细胞突炎是什么?免疫球蛋白是一种免疫球蛋白.脏病综合征 - 脏病综合征血细胞是一种血细胞.

更多相关视频

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Isolation of Glomeruli and In Vivo Labeling of Glomerular Cell Surface Proteins

Published on: January 18, 2019

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

相关概念视频

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...