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Updated: May 31, 2025

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在OSCC中对外长非编码RNAMALAT1的评估,与异形和正常相比:一个横截面研究

Ramya Sekar^1,2, Selvaraj Jayaraman¹, VishnuPriya Veeraraghavan¹

¹Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600077, India.

Journal of oral biology and craniofacial research

|January 24, 2025

概括

外体MALAT1在口腔状细胞癌 (OSCC) 中过度表达,与PI3K/AKT通路相关. 这一发现强调了MALAT1作为早期OSCC检测和个性化治疗策略的潜在生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物生物标志物

背景情况:

口腔状细胞癌 (OSCC) 提出了诊断和治疗方面的挑战.
长非编码RNAs (lncRNAs) 越来越多地被认为是它们在癌症中的作用.
外体细胞促进细胞间通信,并可以携带诊断标记.

研究的目的:

研究外体MALAT1在口腔发育不良和OSCC进展中的作用.
评估外体MALAT1与PI3K/AKT通路之间的关联.
探索MALAT1作为最小侵入性OSCC诊断和治疗的潜在生物标志物.

主要方法:

横截面研究设计. 截面研究设计.
从口腔发育不良,OSCC和健康对照患者的血样本中分析外体RNA.
定量实时聚合酶连锁反应 (qPCR) 用于测量MALAT1,PI3K,AKT1和PTEN的表达.
统计分析包括ANOVA和Tukey的后期测试.

主要成果:

与正常对照组相比,外体MALAT1在OSCC中显著过度表达 (p < 0.001).
在肌肉发育不良和正常组之间没有观察到MALAT1表达的显著差异.
发现MALAT1表达和PI3K/AKT/PTEN途径组件在形和OSCC组之间存在显著的相关性 (p < 0.001).
双对对比显示,在不同发育不良阶段的MALAT1表达中存在显著的关联 (p < 0.001).

结论:

外体MALAT1是OSCC的一个有前途的生物标志物.
MALAT1通过PI3K/AKT途径影响OSCC的进展.
对MALAT1的进一步研究可能会导致OSCC的新型诊断和治疗策略.

关键词:

发育不良症发育不良症是什么外基因组是外基因组的组成部分.没有编码的RNA.这是OSCCCC的OSCC.瘤微环境是一个微环境.在cnRNA中.

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