牙周病原体和肥胖症在不同年龄组的心血管风险的背景下
Georgy Leonov1, Yurgita Varaeva1, Elena Livantsova1
1Department of Cardiovascular Pathology and Diet Therapy, Federal Research Centre for Nutrition, Biotechnology and Food Safety, Moscow, Russia.
Frontiers in oral health
|January 24, 2025
概括
这项研究揭示了特定牙周病原体与心血管疾病风险因素 (如肥胖和高血压) 之间的联系,特别是在年轻人中. 需要进一步的研究来了解这些口腔全身健康连接.
科学领域:
- 口腔微生物学 口腔微生物学
- 心血管流行病学心血管流行病学
- 非传染性疾病研究的研究.
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 年轻人群体中心血管疾病的增加令人担忧.
- 肥胖及其并发症显著增加心血管疾病的风险.
研究的目的:
- 研究六种关键牙周病原体与心血管疾病风险因素之间的关联.
- 分析这些跨不同年龄和体重指数 (BMI) 层之间的关系.
- 探索口腔病原体,肥胖和全身健康标志物之间的联系.
主要方法:
- 研究了189名个人,通过PCR评估身体成分,血液标记物 (脂质,葡萄糖,细胞因子) 和口腔病原体.
- 使用SCORE和FINDRISC等级来计算心血管和糖尿病风险.
- 根据年龄和BMI分层参与者,以确定特定的关联.
主要成果:
- 诸如F. nucleatum* (89.2%) 和A. actinomycetemcomitans* (63.4%) 这样的病原体的流行率很高.
- 年龄和BMI显著影响了病原体的分布,年轻的肥胖人群表现出更高的P.intermedia和T.forsythia.
- *P. gingivalis*与高血压/失脂症有关; *P. intermedia*与高血压/肥胖有关; *T. denticola*与肥胖/失脂症/吸烟有关; *T. forsythia*与失脂症有关.
结论:
- 牙周病原体可能与心血管疾病风险因素有关,例如吸烟,肥胖,高血压和脂质失调.
- 进一步调查至关重要,以确定口腔微生物群,肥胖和全身疾病之间的因果关系.
- 制定减轻年轻成年人口腔健康相关心血管疾病风险因素的策略至关重要.
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