糖尿病患者心脏代谢指数和糖尿病病之间的关系
Jianping Kong1, Wenting Tao2, Yuhong Sun3
1Department of Nephrology, Nanjing Lishui People's Hospital, Zhongda Hospital Lishui Branch, Southeast University, Nanjing, China.
Frontiers in endocrinology
|January 24, 2025
概括
心脏代谢指数 (CMI) 与患有糖尿病的美国成年人患糖尿病病 (DKD) 的风险增加有关. 当CMI超过1.7时,这种关联变得显著,特别是在吸烟者中.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
背景情况:
- 心脏代谢指数 (CMI) 与各种健康状况有关,包括糖尿病和功能障碍.
- CMI和糖尿病病 (DKD) 之间的特定关系需要进一步阐明.
研究的目的:
- 调查心脏代谢指数 (CMI) 与患有糖尿病的美国成年人群中患糖尿病病 (DKD) 的风险之间的相关性.
主要方法:
- 利用了2003-2018年国家健康和营养检查调查 (NHANES) 的数据.
- 采用多变量逻辑回归,通用添加模型 (GAM) 具有平滑的曲线拟合,以及两阶段回归分析.
- 进行了子组分析和相互作用测试,以探索CMI-DKD关系的变化.
主要成果:
- 在调整多个混因素后,在较高的CMI水平和增加的DKD风险 (OR=1.11,95%CI:1.05,1.17,p<0.0001) 之间发现了显著的正相关性.
- 观察到一种非线性关系,CMI=1.7的值效应,超过此值后,DKD的风险增加.
- 这种联系在不同吸烟状态的个体中尤为明显 (p的相互作用=0.0216).
结论:
- 糖尿病患者心脏代谢指数 (CMI) 升高与糖尿病患者糖尿病病 (DKD) 风险增加显著相关.
- 存在值效应,CMI水平高于1.7表明风险增加.
- 建议进行进一步的大规模前性研究以验证这些发现.
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