终身压力因素与多发性硬化症的隐形症状有关
Carri S Polick1,2, Tiffany J Braley3, Robert Ploutz-Snyder4
1School of Nursing, Duke University, Durham, NC 27710, USA.
概括
儿童和成人压力因素显著影响多发性硬化症 (MS) 症状,特别是疲劳,疼痛和精神问题. 压力因素的严重程度,而不仅仅是数量,对于了解MS患者 (PwMS) 终身影响至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 儿童时期的压力因素可以改变成年人的压力感知,并在一生中积累.
- 有证据表明,儿童时期的逆境与成年患有多发性硬化症 (MS) 的疲劳,疼痛和精神问题有关.
- 需要一个全面的寿命方法来了解压力因素对MS患者 (PwMS) 的影响.
研究的目的:
- 检查儿童和成人时期的压力特征 (数量,严重程度) 如何影响PwMS中的疲劳,疼痛干扰和精神病发病率.
- 研究整个生命周期中压力因素对MS症状的累积影响.
- 探索压力因子严重程度与数量的作用,以预测PwMS的结果.
主要方法:
- 通过国家多发性硬化症协会分发的在线调查进行横截面研究.
- 阶层块回归建模,以评估人口,儿童压力因素和成人压力因素的贡献.
- 分析包括713名MS患者 (PwMS) 在最终的分析模型中.
主要成果:
- 儿童和成人压力因素都在PwMS中显著预测了疼痛干扰和精神病发病率.
- 成人压力因素的严重程度与精神病发病率独立相关 (P < 0.0001).
- 儿童时期的压力因素显著导致疲劳 (LR测试P < 0.0001),严重程度与疲劳的可能性 (P = 0.03) 和程度 (P < 0.001) 相对相关.
结论:
- 在PwMS中,寿命压力因素与疲劳,疼痛和精神病发病率之间存在关系.
- 压力因素的严重程度是一个关键因素,可能会被基于计数的创伤指标忽视.
- 临床医生和研究人员在管理PwMS症状时应考虑终身应激暴露.
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