微RNA-155作为生物标志物及其在乳腺癌中的诊断价值:系统性审查

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Bann Siang Yeo¹, Wen Xuan Lee¹, Rozi Mahmud²

¹Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.

World journal of oncology

|January 24, 2025

概括

本综述探讨了microRNAs (miRNAs),特别是miR-155,作为乳腺癌的潜在诊断生物标志物. 虽然miR-155显示出希望,但需要进一步的临床研究来确认其诊断准确性和临床实用性.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

微RNA (miRNA) 越来越多地被研究为乳腺癌的生物标志物和治疗点.
miR-155涉及乳腺癌的发展,调节关键的细胞过程,如增殖和转移.
之前对miR-155作为乳腺癌生物标志物的研究产生了多样化的结果.

研究的目的:

系统地审查和综合有关miR-155作为乳腺癌潜在诊断生物标志物的现有数据.
在各种生物样本中评估miR-155的诊断性能.
为了将miR-155表达与乳腺癌临床病理特征相关联.

主要方法:

对SCOPUS和PubMed数据库进行系统的文献搜索.
包括和排除的标准适用于376个记录,选择了26个原始文章.
在血清,血,活检,尿液,乳头吸血液,血清外体和外围血液单核细胞中分析miR-155的表达.
接收器操作特征 (ROC) 分析以评估诊断灵敏度和特异性 (曲线下的面积 - AUC).

主要成果:

在不同的样本类型中分析了miR-155表达.
研究了miR-155表达和临床病理特征之间的相关性.
记录了AUC值以评估诊断潜力.

结论:

miR-155显示出作为乳腺癌诊断生物标志物的潜力.
限制包括小样本大小,不一致的RT-qPCR控制和可变的灵敏度/特异性.
进一步的临床验证对于将miR-155研究转化为临床实践至关重要.

关键词:

生物标志物生物标志物乳腺癌乳腺癌乳腺癌诊断诊断诊断诊断一个米R-1555,一个米R-155.这是一个微型RNA.系统性审查系统性审查

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相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...