菌中介菌通过细胞亡调节促进同步多重原发性肺癌的进展
Yi Deng1,2,3,4, Zhi Xiang Dong1,3, Gao Hua Yang5
1Faculty of Life and Biotechnology, Kunming University of Science and Technology, Kunming, China.
Frontiers in immunology
|January 24, 2025
概括
同步多发性原发性肺癌 (sMPLC) 与肺微生物组障碍有关. 在sMPLC肺部中发现细菌Streptococcus intermedius富含,可能影响癌症的进展.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 肺微生物组失生症与肺癌的发展有关.
- 同步多重原发性肺癌 (sMPLC) 由于其复杂性和不良预后,存在重大临床挑战.
- 肺微生物组在sMPLC病原发生中的特定作用尚不清楚.
研究的目的:
- 为了研究患有sMPLC.患者的肺微生物组合.
- 确定与sMPLC发展和进展相关的特定微生物参与者.
- 探索已识别的细菌对肺癌细胞行为的影响.
主要方法:
- 16S rRNA测序用于肺微生物组分析.
- 定量PCR (qPCR) 用于确定肺组织中的细菌数量.
- 流式细胞计量以评估肺瘤细胞中的细胞周期和细胞亡.
主要成果:
- sMPLC的发生与肺微生物组的改变相关.
- 在sMPLC患者的肺部中,Streptococcus intermedius的含量显著增加,特别是在瘤组织中.
- 观察到S. intermedius可以抑制细胞灭亡并缩短肺癌细胞的细胞周期.
- 在sMPLC患者的口腔微生物组不平衡和肺微生物组组成之间发现了强烈的关联.
结论:
- 这项研究描述了sMPLC中的肺微生物群,并确定S. intermedius作为一个关键的细菌菌株.
- S. intermedius可能在sMPLC的发病过程中发挥重要作用.
- 这些发现为sMPLC诊断和治疗策略提供了新的见解.
相关概念视频
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
01:31The Intrinsic Apoptotic Pathway
6.2K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.2K