抗生素介导的失生症导致炎症途径的激活
Jemma J Taitz1,2, Jian Tan1,2, Duan Ni1,2
1Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Frontiers in immunology
|January 24, 2025
概括
过度使用抗生素会破坏肠道微生物群,改变代谢物,并可能导致IBD等炎症性疾病的发生. 虽然免疫平衡在很大程度上被保留了,但改变的脊髓细胞反应突出显示了免疫反应失调的风险.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群对宿主健康至关重要,产生代谢物和信号分子.
- 过度使用抗生素引发了人们对微生物群破坏和免疫平衡的担忧.
- 抗生素诱导的抗生素失调对免疫反应的影响尚未完全理解.
研究的目的:
- 研究抗生素对肠道微生物群组成和代谢物的影响.
- 评估抗生素诱导的抗生素失调对免疫细胞概况和功能的影响.
- 探索抗生素消费与炎症性肠病 (IBD) 发病率之间的关系.
主要方法:
- 小鼠接受了万科米辛,波利米辛B或PBS四周的治疗.
- 用16S rRNA测序分析了肠道微生物组成.
- 测量了代谢物,免疫细胞概况 (流细胞计) 和细胞因子产生 (TNF).
- 流行病学分析将抗生素使用与IBD发病率相关联.
主要成果:
- 抗生素降低了肠道微生物的多样性,改变了短链脂肪酸水平 (乙酸盐,丁酸盐,酸盐,酸盐).
- 中腔淋巴结和脏中的免疫细胞种群显示了轻微的变化.
- 接受抗生素治疗的小鼠的脊髓细胞在体外刺激时产生了显著更多的TNF.
- 在抗生素消费和IBD发病率之间发现了正相关性.
结论:
- 抗生素诱导的肠道失调改变了代谢物概况,但在很大程度上保持了稳定状态下的免疫平衡.
- 乱的微生物群导致细胞中TNF的产生升高,这表明有免疫调节失调的倾向.
- 抗生素介导的干扰可能会为TNF相关的炎症性或自身免疫性疾病编程宿主.
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