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Updated: May 31, 2025

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评估基于固体脂质纳米粒子的药物递送系统的实验方法

Paurnima Talele1, Anand Jadhav2, Saugata Sahu3

  • 1Shri Guru Gobind Singhji Institute of Engineering & Technology, Nanded 431606, India.

Analytical methods : advancing methods and applications
|January 24, 2025
PubMed
概括

固体脂质纳米颗粒 (SLN) 作为药物载体具有优势. 本综述详细介绍了分析技术,以表征SLN的物理化学特性和药物递送效率,这对其发展至关重要.

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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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