"观察和等待" (WoW) 研究的短期结果:前性队列研究
Daniel Rydbeck1,2, Najia Azhar3,4, Lennart Blomqvist5,6
1Department of Surgery, SSORG-Scandinavian Surgical Outcomes Research Group, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg, Gothenburg, Sweden.
BJS open
|January 24, 2025
概括
瑞典国家观察和等待研究发现,早期直肠癌复发率与之前的研究相似. 大多数复发的患者可以成功接受具有治愈意图的救援手术.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 在全球范围内,尽管长期瘤安全性1级证据有限,但对直肠癌的非手术治疗 (观察和等待) 越来越多.
- 2017年,瑞典启动了一项全国性前性研究,以评估观察和等待策略的实施情况.
研究的目的:
- 报告全国直肠癌观察和等待研究的短期结果.
- 为了评估局部再生率,远程转移率,并在6个月的随访中评估救援手术后的结果.
主要方法:
- 包括经过活检证明的直肠癌患者在新辅助疗法后获得临床完整反应.
- 采用了机会主义的观察和等待方法,在参与中心进行了包容和后续管理.
- 主要结局:3年无病生存期; 报告的次要结局:6个月局部再生,远程转移和救援手术结果.
主要成果:
- 在2017年1月至2023年2月期间,包括了211名临床完整反应的患者.
- 16% (33/211) 的患者在6个月内经历了可疑的复发; 94% (32/33) 接受了具有治愈意图的救援手术.
- 在6个月内,1.4% (3/211) 的患者观察到远程转移.
结论:
- 这项瑞典国家观察和等待研究中的短期复发率与现有文献一致.
- 大多数经历早期再生的患者都成功地接受了救援手术治疗,并保持了治疗意图.
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