分析2型糖尿病患者和勃起功能障碍患者与有机勃起功能障碍相关的危险因素
Mingming Lu1,2, Dawei Ni1, Wei Wu1
1Department of Urology, The Affiliated Hefei Hospital of Anhui Medical University (The Second People's Hospital of Hefei), 230011 Hefei, Anhui, China.
Discovery medicine
|January 24, 2025
概括
这项研究开发了一种风险预测模型,使用临床数据在2型糖尿病患者中识别有机勃起功能障碍 (ED). 该模型有效地预测有机性勃起障碍,有助于更好的诊断和治疗策略.
科学领域:
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 心血管医学 心血管医学
背景情况:
- 糖尿病勃起功能障碍 (DMED) 是糖尿病的常见并发症.
- 准确区分勃起功能障碍 (ED) 类型对于有效治疗至关重要.
- 目前用于ED类型区分的临床工具有限.
研究的目的:
- 开发和验证2型糖尿病患者有机性勃起障碍风险预测模型.
- 用随时可用的临床数据来评估ED风险.
- 提高DMED的诊断能力.
主要方法:
- 对250名2型糖尿病患者的临床数据进行了回顾性分析.
- 风险因素选择的拉索回归.
- 多变量物流回归以建立风险预测模型.
- 通过引导方法进行内部验证,并通过C指数,校准曲线,DCA和ROC曲线进行评估.
主要成果:
- 168名 (67.2%) 患者被诊断出有机性勃起障碍.
- 确定的危险因素包括糖尿病持续时间,LDL-C,RDW,心动脉内膜-介质厚度,糖尿病视网膜病变,病变和外围神经病变.
- 该模型的C指数为0.827,校准良好,临床效用良好 (DCA:28%-100%的门).
结论:
- 建立了一种初步的风险预测模型,用于2型糖尿病中的有机性勃起障碍.
- 该模型整合了关键的临床变量:糖尿病持续时间,动脉内膜介质厚度,糖尿病并发症 (视网膜病变,脏病,神经病变),RDW和LDL-C.
- 开发的模型证明了这个人群中有机ED的强大预测性能.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Disorders of the Male Reproductive System
311
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
311
Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Pathophysiology of Diabetes
854
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
854
Diabetes: Symptoms, Diagnosis, and Complications
500
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
500


