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新型快速设置和机械强大的酸纸封闭水泥与甲福林释放以增强牙纸干细胞

Mohammad Alenizy^1,2,3, Abdullah Alhussein⁴, Nader Almutairi^1,2,5

¹Dental Biomedical Sciences Ph.D. Program, Graduate School, University of Maryland, Baltimore, MD 21201, USA.

Bioengineering (Basel, Switzerland)

|January 24, 2025

概括

一种新的酸水泥与酸盐 (CPCC) 加载甲 (CPCC-Met) 装载的酸水泥比矿物三氧化物聚合物 (MTA) 设置更快,并显示出牙纸修复的希望. 这种具有成本效益的材料支持人类牙纸干细胞的活力和增殖.

科学领域:

生物材料科学生物材料科学
恢复性牙科恢复性牙科
牙纸生物学牙纸生物学

背景情况:

传统的纸封装剂,如矿物三氧化聚合物 (MTA),具有局限性,包括缓慢的设置时间和高成本.
甲胺显示了面再生的潜力,并通过向肉皮细胞来增强牙合成.

研究的目的:

开发一种具有增强物理机械性能的新型酸盐水泥与酸盐 (CPCC).
将甲胺纳入CPCC (CPCC-Met) 并评估其释放动力学.
评估人类牙纤维干细胞 (hDPSC) 对CPCC-Met.的生物反应.

主要方法:

CPCC的制定和测试与MTA进行了测试,以确定时间和物理机械性能.
在不同度 (0-150微克) 中将甲胺纳入CPCC,并对其释放量进行量化.
使用CPCC-Met培养hDPSCs,并使用活/死成像和扫描电子显微镜 (SEM) 评估细胞附着,增殖和活力.
使用单向ANOVA进行统计分析.

主要成果:

与MTA (123分钟) 相比,优化的CPCC配方 (3.25:1比) 的设置时间显著减少 (41.5分钟).
从CPCC-Met中释放的甲胺是剂量依赖的.
对于CPCC-Met.,SEM分析显示出一个多孔的,富含酸的表面.
在所有测试组中都观察到高hDPSCs活力 (>93%在1天,>95%在4天,≈98%在7天) 和增殖,没有显著差异.

结论:

新的CPCC-Met材料显示了显著更快的定时间和与MTA相似的生物相容性.
据CPCC-Met显示,CPCC-Met具有作为纸封盖的成本效益高的替代品的潜力,通过受控的甲胺释放促进牙修复.

关键词:

生物活性物质是生物活性材料.生物相容性生物相容性基多酸盐的使用方法牙再生牙再生直接封闭纸纸.甲胺是一种甲胺.

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