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在三阴性乳腺癌中,雄激素受体过度表达的双重功能:一个复杂的预后标志物
Umay Kiraz1,2, Emma Rewcastle1, Silja K Fykse1
1Department of Pathology, Stavanger University Hospital, 4011 Stavanger, Norway.
Bioengineering (Basel, Switzerland)
|January 24, 2025
概括
使用数字图像分析 (DIA) 对三阴性乳腺癌 (TNBC) 的客观雄激素受体 (AR) 评估揭示了其预后价值. 高AR-DIA (≥10%) 影响TNBC亚组的生存率不同,指导向治疗决策.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 生物标志物发现发现
背景情况:
- 三重阴性乳腺癌 (TNBC) 是异质的,其中的一个子集表达了雄激素受体 (AR).
- 目前对AR阳性的值及其在TNBC中的临床意义仍然不一致.
- 与客观方法相比,对AR表达的主观评估可能缺乏可复制性.
研究的目的:
- 调查客观的雄激素受体 (AR) 评估在三阴性乳腺癌 (TNBC) 的预后价值.
- 为了比较主观评分 (AR-Manual) 与AR表达的自动化数字图像分析 (AR-DIA).
- 确定高AR表达 (≥10%的AR-DIA) 在TNBC预后和潜在的向治疗中的临床意义.
主要方法:
- 基于人口的TNBC队列 (n=198) 的回顾性分析,长期随访 (4-383个月).
- 使用主观评分 (AR-Manual) 和自动化数字图像分析 (AR-DIA) 评估AR表达.
- 统计分析包括多变量分析,以确定独立的预后因素.
主要成果:
- 10%的AR-DIA切断值是远程转移最强的负预测因素 (p=0.008).
- 高的AR-DIA与较低的等级和扩散相关,但也与较大的瘤,远程转移和淋巴结阳性相关.
- 淋巴结状况和AR-DIA之间的相互作用是最强的预后因素,其次是纤维化焦点,MAI和sTILs.
结论:
- 自动化数字图像分析 (AR-DIA) 提供了在TNBC中对AR表达的可重复评估.
- 高AR-DIA (≥10%) 具有双重预后作用,在各种TNBC亚组中不同影响生存率.
- 对AR的评估对于预后和识别可能受益于AR向治疗的患者至关重要,特别是在不利的子组中.
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