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关于人类椎脊柱纵向带年龄依赖的生物机械性质的试点研究
Narendra Singh1,2, Ana Trajkovski1, Jovan Trajkovski1
1Chair of Modelling in Engineering Sciences and Medicine, Faculty of Mechanical Engineering, University of Ljubljana, Aškerčeva c. 6, 1000 Ljubljana, Slovenia.
Bioengineering (Basel, Switzerland)
|January 24, 2025
概括
衰老显著降低了椎带的机械强度和弹性,特别是前纵带带 (ALL) 和后纵带带 (PLL). 这些发现凸显了影响脊柱稳定性的与年龄相关的变化.
科学领域:
- 生物力学 生物力学
- 脊椎解剖学 脊椎解剖学
- 老年学是一门学科.
背景情况:
- 椎带,包括前沿带 (ALL) 和后沿带 (PLL),对于维持脊柱稳定性至关重要.
- 衰老与组织性质的变化有关,可能会影响带功能并导致肌肉骨系统疾病.
研究的目的:
- 研究衰老对人类椎带 (ALL和PLL) 机械性能的影响.
- 量化与年龄相关的硬度变化,终极应力和终极拉伸.
主要方法:
- 分析了来自12位捐赠者的18个人类椎带样本 (8个ALL,10个PLL).
- 样本分为两个年龄组:50岁以下和50岁以上.
- 单轴应力拉伸测试用于评估初始触角刚度 (E0),最大触角刚度 (Em),终极应力 (Pu) 和终极拉伸 (λu).
主要成果:
- 老化导致ALL和PLL的最大触角刚度 (p=0.0147),最终应力 (p=0.0009) 和最终伸展 (p=0.0024) 在统计学上显著减少.
- 当不考虑年龄时,ALL和PLL的机械行为似乎相似,但出现了特定于年龄的差异.
结论:
- 衰老会对椎带的机械完整性产生负面影响,降低它们承受压力和变形的能力.
- 这些因年龄引起的ALL和PLL机械性质的变化可能会对老年人的脊柱稳定性和受伤风险产生影响.
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