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短期限制身体和社会活动对大脑结构和连接性的影响

Yajuan Zhang¹, Lianghu Guo¹, Zhuoyang Gu¹

¹School of Biomedical Engineering and State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai 201210, China.

|January 24, 2025

概括

短期的锁定导致大脑灰质体积减少和功能连接的改变. 虽然在限制解除后,一些大脑连接恢复了,但结构性变化可能会持续存在,突出显示隔离.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
公共卫生公共卫生

背景情况:

人们对长期监禁对身体和精神健康的影响存在担忧.
虽然COVID-19封锁与抑郁和焦虑的增加有关,但对大脑功能短期限制的影响不太清楚.

研究的目的:

在短期锁定后,研究大脑灰质体积 (GMV) 和功能连接 (FC) 的纵向变化.
将锁定限制期间和之后的大脑结构和功能与锁定前的基线进行比较.

主要方法:

磁共振成像 (MRI) 数据从参与者处在三个时间点收集:锁定前,锁定后两个月和锁定后四个月.
在20-29名参与者中,对灰质体积 (GMV) 和功能连接 (FC) 的纵向分析.

主要成果:

在锁定后的右直结和结中观察到灰质体积 (GMV) 的显著减少,四个月后进一步观察到变化.
在默认模式网络 (DMN) 和传感器/注意网络之间功能连接 (FC) 降低,在锁定后检测到.
在封锁限制解除四个月后,功能连接 (FC) 的部分恢复观察到.

结论:

大脑功能连接 (FC) 表现出塑性和隔离后恢复的潜力.
观察到的结构变化可能会产生长期影响,需要进一步调查.
研究结果提供了对隔离的神经效应的见解,并为潜在的康复策略提供了信息.

关键词:

功能连接性的功能连接性封锁环境封锁环境纵向研究是一种纵向研究.静止状态的fMRI进行.结构性核磁共振成像 (MRI)

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Brain Imaging

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