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增长分化因子15水平与艾滋病毒相关的神经认知障碍有关:试点研究
Ali Boustani1, Mary K Ford1, Jacqueline R Kulbe1
1Department of Psychiatry, University of California San Diego, San Diego, CA 92093, USA.
Brain sciences
|January 24, 2025
概括
脑组织中增长差异化因子15 (GDF15) 水平升高与艾滋病毒感染者 (PWH) 的艾滋病毒相关神经认知障碍 (NCI) 有关. 这表明GDF15可能是检测和监测认知衰退的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 艾滋病毒相关的神经认知障碍 (NCI) 在艾滋病毒感染者 (PWH) 中仍然存在,尽管有抗逆转录病毒治疗 (ART).
- 慢性神经炎症,即使有病毒抑制,也会导致与艾滋病毒相关的NCI病变.
- 增长分化因子15 (GDF15) 与炎症和代谢应激反应以及神经疾病有关.
研究的目的:
- 调查生长差异化因子15 (GDF15) 表达和与艾滋病毒相关的神经认知障碍 (NCI) 之间的关系.
- 探索GDF15作为HIV (PWH) 患者中NCI的潜在生物标志物.
主要方法:
- 对脑脊液 (CSF) 和已故PWH脑组织中GDF15水平的分析.
- 使用了免疫洗,免疫组织化学,双免疫标记和ELISA技术.
- 根据神经心理检查,将PWH分为神经认知不受损 (NUI) 和与艾滋病毒相关的NCI组.
主要成果:
- 与NUI PWH相比,NCI的PWH的前额皮层中GDF15蛋白质水平显著更高.
- 在有NCI的PWH中观察到更高的血病毒载荷 (5.38 log10副本/毫升) 与NUI PWH (3.56 log10副本/毫升).
结论:
- GDF15可能有助于艾滋病毒相关的NCI的发病,可能是通过神经炎症途径.
- GDF15水平与认知障碍严重程度之间的强烈相关性凸显了其作为PWH中NCI早期检测和监测生物标志物的潜力.
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