维生素K2缺乏的患病率及其与冠状动脉疾病的关联:一个病例对照研究
Sameh A Ahmed1, Abdulaziz A Yar1, Anas M Ghaith2
1Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Madinah 42353, Saudi Arabia.
Diseases (Basel, Switzerland)
|January 24, 2025
概括
维生素K2缺乏症在冠状动脉疾病 (CAD) 患者中很常见,在不稳定的心痛中观察到的最低水平. 这表明将维生素K2纳入CAD风险评估和管理策略.
科学领域:
- 心血管医学 心血管医学
- 营养生物化学 营养生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 维生素K2类似物可以减少血管化,并在冠状动脉疾病 (CAD) 中提供好处.
- 了解不同CAD类型的血清维生素K2水平对于风险分层至关重要.
- 维生素K2影响抗蛋白和先天免疫反应.
研究的目的:
- 为了研究血清维生素K2类比水平与CAD之间的关联.
- 为了检查维生素K2水平与CAD患者的临床风险因素之间的相关性.
- 为了在不同CAD亚型中比较维生素K2水平.
主要方法:
- 一个病例对照研究,比较CAD患者和健康对照.
- 使用UPLC-MS/MS测量了menaquinone-4 (MK-4) 和menaquinone-7 (MK-7) 的血清度.
- 评估了CAD风险因素,并与维生素K2类比水平相关联.
主要成果:
- 与对照组相比,CAD患者的血清MK-4和MK-7水平显著降低 (p < 0.001).
- 患有急性冠状动脉综合征的患者显示MK-4和MK-7水平降低.
- 不稳定的胸痛患者表现出MK-4和MK-7的血清水平最低.
结论:
- 维生素K2缺乏症在CAD患者中很普遍.
- 在MK-4和MK-7中,最显著的降低是在不稳定的心痛中观察到的.
- 包括维生素K2途径在内的综合方法对于CAD风险分层和管理至关重要.
相关概念视频
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.1K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.1K
Role of Vitamins in Maintaining Bone Health
3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K
Ischemic Heart Disease: Overview
1.2K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
1.2K
Vitamins
548
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
548
Disorders of Hemostasis
693
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
693
Coronary Circulation
2.2K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
2.2K


