胆囊托基宁 (CCK) 是中介者之间的营养摄入量和生殖腺发育在teleosts
Hangyu Li1, Hongwei Liang1,2, Xiaowen Gao1
1Hubei Hongshan Laboratory, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.
Cells
|January 24, 2025
概括
营养摄入量通过下丘脑-垂体-腺轴影响鱼类的繁殖. 神经 cholecystokinin (CCK) 作为营养传感器,刺激生殖激素的释放和teleosts. gonadal的发展.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 水产养殖是水产养殖的一种方式.
背景情况:
- 营养摄入对于生殖腺发育至关重要,但潜在的机制尚不清楚.
- 胆囊托基宁 (CCK) 是一个下丘脑腹神经,受食物摄入量和血糖水平的影响.
- CCK及其受体在草的下丘脑-垂体-腺 (HPG) 轴上高度表达,这表明它在鱼类繁殖中的作用.
研究的目的:
- 为了研究下丘脑CCK在调节远距离体内生殖腺发育中的作用.
- 为了确定CCK是否会影响下丘脑-垂体-腺 (HPG) 轴和生殖激素表达.
- 阐明CCK对垂体和卵巢细胞的直接影响.
主要方法:
- 与食物摄入量和血糖相关的下丘脑CCK表达的分析.
- 在草HPG轴中评估CCK和受体表达.
- 在体内和体外使用初级细胞培养 (垂体和卵巢) 和单细胞RNA测序的研究.
主要成果:
- 脑下垂体CCK表达是由通过血糖通过食物摄入来调节的.
- CCK显著刺激性腺激素释放激素-3 (GnRH3) 和卵泡刺激激素 (FSH) 的合成和分泌.
- 基因直接诱导细胞中关键卵巢基因 (lhr,fshr,cyp19a1a) 的表达.
结论:
- 脑下垂体CCK功能作为一个关键的营养传感器在teleosts.
- 通过HPG轴,CCK在调节鱼类繁殖方面发挥着重要作用.
- 这些发现提供了对淋巴体发育的神经内分泌控制的见解,以应对营养状况.
关键词:
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