Jove
Visualize
联系我们

相关概念视频

Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox.

Science (New York, N.Y.)·2025
Same author

Integrated proteome and lipidome analyses place OCIAD1 at the mitochondria-peroxisome intersection balancing lipid metabolism.

Journal of cell science·2025
Same author

Organelle Membrane Extensions in Mammalian Cells.

Biology·2023
Same author

Fission Impossible (?)-New Insights into Disorders of Peroxisome Dynamics.

Cells·2022
Same author

PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor.

Journal of cell science·2022
Same author

Regulating peroxisome-ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β.

The Journal of cell biology·2022
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jun 14, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.6K

在斑马鱼中建模过氧体疾病.

Chenxing S Jiang1, Michael Schrader1

  • 1Biosciences, Faculty of Health and Life Sciences, University of Exeter, Exeter EX4 4QD, UK.

Cells
|January 24, 2025
PubMed
概括
此摘要是机器生成的。

斑马鱼的模型提供了宝贵的洞察力,对Peroxisomal功能和疾病. 这些模型有助于理解过氧体在健康,疾病和发育中的作用,促进对过氧体状况的药物查.

关键词:
丹尼奥·雷里奥 (Danio Rerio) 是一个在FIS1中,FIS1是FIS1.皮克斯 (PEX) 是一个PEX.这就是VWA8WA.脂肪酸β-氧化脂肪酸β-氧化脂质新陈代谢 脂质新陈代谢代谢障碍 代谢障碍 代谢障碍器官生物发生的生物发生.过氧化物体是多氧化物体.

更多相关视频

High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake
11:30

High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake

Published on: October 27, 2016

10.4K
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
00:08

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

5.6K

相关实验视频

Last Updated: Jun 14, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

20.6K
High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake
11:30

High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake

Published on: October 27, 2016

10.4K
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
00:08

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

5.6K

科学领域:

  • 细胞生物学 细胞生物学
  • 遗传学 遗传学 是一个
  • 发展生物学 发展生物学

背景情况:

  • 过氧体是参与脂质代谢和氧化还原平衡的重要器官.
  • 过氧体功能障碍与衰老,神经退行,癌症和免疫反应有关.
  • 过氧体生物发生需要过氧素 (PEX基因);缺陷会导致严重的发育和神经系统障碍.

研究的目的:

  • 与人类相比,为斑马鱼提供氧体可视化,代谢功能和蛋白质库存的概述.
  • 介绍斑马鱼模型,用于调查超氧体疾病,包括生物发生缺陷和酶缺乏.
  • 突出斑马鱼模型对双重向的过氧体/线粒体蛋白质,并讨论它们在药物查中的应用.

主要方法:

  • 斑马鱼和人类之间的过氧体特征的比较分析.
  • 建立和表征斑马鱼模型用于特定的过氧体疾病.
  • 利用斑马鱼模型来研究发育过程中的过氧体功能.

主要成果:

  • 斑马鱼作为一个有效的脊椎动物模型,用于研究过氧体生物学和疾病.
  • 已建立的斑马鱼模型准确地代表了人类的多氧体疾病,如Zellweger谱系障碍和上腺核衰竭.
  • 斑马鱼模型促进了对发育中的过氧体作用的调查,并使药物查成为可能.

结论:

  • 斑马鱼是促进我们对健康和疾病中的过氧体功能和功能障碍的理解的强大工具.
  • 斑马鱼模型对于剖析过氧体在发育和疾病发病过程中的复杂作用至关重要.
  • 斑马鱼模型的应用对开发新的治疗策略具有前景,用于过氧体疾病.