在现场凝德克萨米他或乳腺素配方:影响药物输送的物理特征
Daniel Krchňák1, Ľudmila Balážová2, Michal Hanko3
1Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovakia.
Gels (Basel, Switzerland)
|January 24, 2025
概括
这项研究使用德克萨米他 (DEX) 开发了一种在位凝性口腔菌制剂,用于治疗口腔炎. 最好的配方,含有DEX,薄荷精油 (EO) 和基醇 (PG) 在基甲基纤维素 (HPMC) 中,显示出良好的胀和药物释放,刺激程度低.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 鼻腔口腔炎会引起明显的口腔不适和疼痛.
- 目前用于口腔炎的治疗方法在有效性和输送方面存在局限性.
- 口腔粘膜药物递送系统为局部和持续的治疗提供了潜力.
研究的目的:
- 开发和表征一种在现场凝或菌体配方,用于甲 (DEX) 输送.
- 评估精油 (EO) 和溶解对配方特性的影响.
- 评估开发系统的粘粘性,物理和体外释放特性.
主要方法:
- 用不同的聚合物和薄荷EO制备三系列DEX或乳液配方.
- 物理性质的评估:pH,风病学,胀和纹理分析.
- 在体外药物释放研究中,蛋测试在胆膜上 (HET-CAM) 刺激,和福里埃变换红外光谱 (FT-IR) 兼容性.
主要成果:
- 基于基甲基纤维素 (HPMC) 的配方与薄荷EO和基醇 (PG) 显示最佳的胀 (700 ± 46%) 和药物释放 (34.7 ± 5.9%).
- 该配方表现出足够的粘粘性和低刺激潜力 (HET-CAM).
- FT-IR分析证实DEX和配方辅助剂之间没有化学不兼容性.
结论:
- 在现场凝粘膜粘合系统显示了增强的甲甲的口腔粘膜药物递送的希望.
- 开发的基于HPMC的配方提供了潜在的有效和安全的治疗口腔口炎.
- 优化的配方设计可以提高治疗疗效,用于管理疼痛的口腔病变.
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