康布查与植物纤维素相比,以获得负担得起的粘膜粘合剂 (纳米) 配方
Ioana Popa-Tudor1, Naomi Tritean1,2, Ștefan-Ovidiu Dima1
1Polymers and Bioresources Departments, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, Splaiul Independentei nr. 202, Sector 6, 060021 Bucharest, Romania.
Gels (Basel, Switzerland)
|January 24, 2025
概括
与植物纳米纤维素相比,细菌纳米纤维素水凝显示出优越的细胞活力和用于生物医学应用的粘素结合. 对于这两种材料,对抗氧化和抗菌性质的进一步改进是必要的.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 纤维素纳米纤维 (CNFs) 是有前途的粘粘性纳米水凝在医疗器械,因为他们的水友性,多孔性,生物降解性和生物相容性.
- 细菌纳米纤维素 (BNC) 和植物纳米纤维素 (VNC) 为水凝形成提供了不同的特性.
研究的目的:
- 为了比较细菌纳米纤维素 (来自kombucha) 和植物纳米纤维素 (来自酒厂的花费谷物) 的适用性,用于制造生物医学水凝.
- 评估VNC和BNC水凝的细胞兼容性,抗氧化活性和粘膜粘合性.
主要方法:
- 合成的VNC来自酒厂的花费谷物和BNC来自kombucha膜.
- 准备了VNC和BNC水凝,并描述了它们的物理特性 (不透明度,流动性).
- 评估了水凝-木素相互作用,使用人类牙纤维细胞 (HGF-1) 的细胞兼容性,体外抗氧化活性和抗菌功效.
主要成果:
- 与VNC水凝相比,BNC水凝的粘结效率大约是VNC水凝的两倍.
- BNC水凝显著增强了可活细胞的代谢活性 (对照的107.60%),表明了出色的细胞相容性.
- 通过减少23%的活性氧物种 (ROS),VNC水凝表现出抗氧化活性,而BNC则略微增加了ROS水平. 两种水凝都没有显示抗菌活性.
结论:
- 从kombucha发酵中获得的BNC水凝显示出较大的细胞相容性和粘粘性纳米配方潜力,而不是从酒厂的花费谷物中获得的VNC水凝.
- 需要进一步优化,以提高BNC的抗氧化能力和VNC和BNC水凝的抗菌特性,以便在更广泛的生物医学应用中使用.
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