微乳液和微乳液基凝中的透增强剂:二乙烯糖醇单乙烯和醇醇的比较
Sujata Pandey1, Gabriella Baki1
1Department of Pharmacy Practice, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, 3000 Arlington Ave, Toledo, OH 43614, USA.
Gels (Basel, Switzerland)
|January 24, 2025
概括
这项研究比较了二乙烯糖醇单乙烯 (DGME) 和醇作为皮肤透增强剂在ibuprofen的微乳液. 基于醇的微乳液凝显示出优异的药物透性,这表明更好的局部输送方法.
科学领域:
- 制药科学 制药科学
- 皮肤药物输送 皮肤药物输送
- 配方科学科学 配方科学
背景情况:
- 微乳液被广泛用于增强通过皮肤递送药物.
- 透增强剂对于改善通过皮肤屏障的药物透性至关重要.
- 布洛芬是一种常见的模范药物,用于局部管理研究.
研究的目的:
- 为了比较二乙烯糖醇单乙烯 (DGME) 和醇作为微乳液中透增强剂的疗效.
- 调查油成分,凝剂和水含量对药物释放和透的影响.
- 评估用于局部布洛芬输送的微乳液配方.
主要方法:
- 基于三元相图的四种微乳液的配方.
- 评估物理化学性质,包括pH值和滴滴大小.
- 在体外药物释放和透研究中,使用具有再生纤维素和Strat-M®膜的弗朗茨细胞.
- 使用高性能液体染色学 (HPLC) 量化易布洛芬.
主要成果:
- 所有的微乳液都显示出与皮肤相容的pH值 (4.9-5.6) 和滴滴大小 (119.8-153.3 nm).
- 基于凝的微乳液显示药物释放量显著增加 (59%和64%).
- 与DGME配方相比,含有醇的微乳液凝的药物透率是DGME配方的四倍.
结论:
- 含有醇的微乳液凝是一种有前途的配方,用于局部输送布洛芬.
- 配方优化对于最大限度地提高增强剂的透增强效果至关重要.
- 醇为DGME提供了一个可取的替代品,用于增强局部微乳液中的布洛芬透率.
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