乳腺癌预防和治疗中的植物化学物质:综合性审查
Adil Farooq Wali1, Jayachithra Ramakrishna Pillai1, Sirajunisa Talath1
1Department of Pharmaceutical Chemistry, College of Pharmacy, RAK Medical and Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates.
Current issues in molecular biology
|January 24, 2025
概括
植物化合物如甲基素和烯通过诱导细胞死亡和破坏癌症途径,显示出显著的抗癌益处. 优化输送系统可以提高它们在乳腺癌管理中的有效性.
科学领域:
- 药理学和瘤学 药理学和瘤学
- 植物化学和癌症生物学
背景情况:
- 乳腺癌是全球主要的健康问题.
- 植物衍生化合物 (植物化学物质) 正在广泛研究它们对各种癌症的治疗潜力.
- 本综述侧重于乳腺癌的植物化学物质,检查其来源,作用和安全性.
研究的目的:
- 综合现有关于用于乳腺癌治疗的植物性化合物的研究.
- 探索关键植物化学品的来源,作用机制,协同效应和副作用.
- 讨论先进的输送系统以及乳腺癌管理中的植物化合物的未来研究方向.
主要方法:
- 关于植物资源及其抗癌特性研究的综合文献综述.
- 综合了关于特定植物化学物质的发现,如 катехин, piperlongumine, lycopene, isoflavones 和 cucurbitacins.
- 对作用机制的分析,包括细胞循环停止,细胞亡和信号通路中断 (例如,JAK-STAT3,HER2-整体蛋白,MAPK).
主要成果:
- 某些植物化学物质通过细胞循环停止和细胞亡等机制显示出抗癌益处.
- 关键信号通路 (JAK-STAT3,HER2-整体蛋白,MAPK) 的破坏是一个关键的抗癌机制.
- 还考虑了这些化合物的潜在不良影响.
结论:
- 植物化合物为乳腺癌提供了有希望的治疗策略.
- 通过优化输送系统 (脂质体,纳米颗粒) 提高疗效至关重要.
- 需要进行进一步的研究,包括临床试验,以验证这些发现并推进临床应用.
关键词:
它具有抗癌活性,具有抗癌活性.灭症 (apoptosis) 是一种死亡的过程.黄类化合物 黄类化合物纳米技术是纳米技术.信号通路的抑制抑制信号通路的抑制.有协同效应的效应.有针对性的药物输送.更多相关视频
相关概念视频
02:59Cancer Prevention
6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.0K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
02:56Treatment Resistant Cancers
3.2K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.2K
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
02:34Inhibition of Cdk Activity
4.6K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.6K