在胃食道逆流性疾病中偏好按需费克苏普拉赞治疗:一项前性队列研究
Byung Wook Jung1,2, Chan Hyuk Park3, Chang Soo Eun1
1Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri 11923, Republic of Korea.
费克苏普拉桑在最初和维持期间有效治疗胃食道逆流性疾病 (GERD) 症状. 大多数患者更喜欢按需治疗,表现出与持续治疗相似的症状控制.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学 是一个学科.
背景情况:
- 维持疗法是治疗胃食道逆流症 (GERD) 的关键.
- 与相竞争的酸阻断剂 (P-CABs),如fexuprazan,为GERD管理提供了一种新的方法.
- 关于P-CABs用于GERD维持治疗的数据有限.
研究的目的:
- 评估费克苏普拉桑在GERD维持治疗中的疗效和患者偏好.
- 为了比较持续与按需的fexuprazan治疗,以控制症状.
主要方法:
- 前性,单中心,单臂队列研究.
- 31名患有侵蚀性食道炎和每周出现GERD症状的患者每天接受40毫克的费克苏普拉赞,持续4周,然后选择维持治疗 (连续或按需) 持续4周.
- 使用GERD-Q和PAGI-SYM问卷进行症状评估.
主要成果:
- 在最初的fexuprazan治疗后显著减少症状 (p < 0.001).
- 67.7%的患者选择了按需的维持治疗.
- 连续和按需维持治疗之间的症状评分没有显著差异 (p > 0.05).
结论:
- 费克苏普拉桑在GERD的初始和维持治疗中都显示出有效性.
- 按需的fexuprazan治疗是许多GERD患者的首选和有效选择.
- 患者对按需治疗的偏好并没有影响症状控制.
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