早期ASAS脊椎关节炎睡眠障碍的原因:回顾的长期经验
Francesca Bandinelli1, Andrea Delle Sedie2, Ilenia Mallia3
1Department of Rheumatology, Santa Maria Nuova Hospital, Usl Tuscany Center, 50122 Florence, Italy.
Journal of personalized medicine
|January 24, 2025
概括
睡眠障碍在脊椎关节炎 (SpA) 中很常见,并与炎症性疼痛有关. 早期的SPA患者表现出持续的睡眠问题,随着时间的推移受到疾病活动的影响.
科学领域:
- 类风湿病学 类风湿病学
- 睡眠医学 睡眠医学
- 炎症性疾病 炎症性疾病
背景情况:
- 睡眠障碍 (SD) 是脊椎关节炎 (SpA) 的一个标准,但缺乏明确的定义.
- 在早期SpA (e-SpA) 和长期SpA (l-SpA) 中调查SD可以了解其演变.
- 了解SD与临床参数的关系对于患者管理至关重要.
研究的目的:
- 为了研究早期SPA患者的睡眠障碍.
- 为了比较e-SpA患者的睡眠障碍与长期SpA (l-SpA) 患者.
- 评估睡眠障碍与疾病活动和其他临床参数的相关性.
主要方法:
- 在T1 (2010-2013) 的166名SPA患者中,对SD的横截面分析 (难以开始睡眠,保持睡眠,早起)
- SD与临床参数的比较,包括ASDAS-CRP,BASDAI,m-HAQ-S和疲劳.
- 使用匹兹堡睡眠质量指数 (PSQI) 在T2 (2023-2024) 中对e-SpA患者的长度评估.
主要成果:
- 在T1时,45%的SPA患者报告SD. 在e-SpA中,SD与关节疼痛,BASDAI,疲劳和抑郁相关. 在l-SpA中,SD与焦虑,BASDAI和疲劳相关.
- 在T2时,51.5%的e-SpA患者的睡眠质量差 (高PSQI),与当前疾病活动相关 (ASDAS-CRP,BASDAI).
- 基线疾病活性 (T1-ASDAS-CRP) 预测T2-PSQI,表明长期影响.
结论:
- 睡眠障碍是SPA的一个重要问题,特别是在早期疾病中与炎症性疼痛有关.
- 疾病活动会影响早期和长期SPA的睡眠质量.
- 早期疾病活动可能预测SPA患者的长期睡眠障碍.
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