相关实验视频

Updated: May 31, 2025

In Ovo Feeding of Commercial Broiler Eggs: An Accurate and Reproducible Method to Affect Muscle Development and Growth

In Ovo Feeding of Commercial Broiler Eggs: An Accurate and Reproducible Method to Affect Muscle Development and Growth

Published on: September 20, 2021

尼古丁胺胺利博补充剂对死后线粒体功能和亡激活的影响

Chen Zhu¹, Luke A Whitcomb², Adam J Chicco²

¹Department of Animal Science, University of Connecticut, Storrs, CT 06269, USA.

|January 24, 2025

概括

尼古丁胺胺 рибоoside (NR) 补充剂保护了猪肌肉线粒体,并减少了收获后的亡. 这可能会改善零售展示期间的猪肉颜色稳定性.

科学领域:

线粒体的生物化学
亡研究的研究研究.
肉类科学肉类科学

背景情况:

死亡后的线粒体功能和亡显著影响肉质的发展.
众所周知,尼古丁胺 рибоoside (NR) 补充剂可以改善猪肉的颜色稳定性,但潜在的机制需要阐明.
了解NR对早期死后肌肉生理学的影响,对于优化肉质量至关重要.

研究的目的:

研究NR补充剂对猪骨肌肉早期死后线粒体功能的影响.
为了评估NR对死后肌肉组织中亡激活标记物的影响.
阐明NR补充对肉质特征的影响机制.

主要方法:

在收获前10天,猪被食控制或NR补充饮食.
在死后45分钟和24小时采集了Longissimus dorsi肌肉样本.
分析了线粒体呼吸,线粒体外膜通透性 (MOMP) 和亡蛋白丰度 (BAX,AIF,CASP3).

主要成果:

补充NR减少了与质子泄漏相关的呼吸,并减缓了MOMP的积累和线粒体功能丧失.
在死后45分钟内,NR降低了Bcl-2-关联X (BAX) 丰度.
在死后24小时内,NR增加了成熟的亡诱导因子 (AIF) 丰度.

结论:

补充NR可以保护早期死后猪肌肉中的线粒体整体功能.
补充NR减轻了亡激活,可能增强了肉的颜色稳定性.
这些发现表明NR是一种可行的策略,可以改善零售展示期间的猪肉质量.

关键词:

灭症 (apoptosis) 是一种死亡的过程.线粒体功能线粒体功能尼古丁胺胺里化物猪长极长的猪长极长的猪死亡后的肌肉肌肉.

更多相关视频

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Author Spotlight: Unveiling Mitochondrial Function and Cellular Metabolic Adaptation in Metabolic Diseases

Published on: October 4, 2024

Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils

Published on: June 2, 2023

相关概念视频

Electron Transport Chain: Complex I and II

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...

Mitochondria

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...

Mitochondrial Membranes

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...