在患有阻塞性睡眠呼吸暂停的患者中研究挥发性有机化合物
Chuan Hao Gui1, Zhunan Jia2, Zihao Xing2
1Tan Tock Seng Hospital, 11 Jln Tan Tock Seng, Singapore 308433, Singapore.
Metabolites
|January 24, 2025
概括
通过PTR-MS检测到的呼吸中的挥发性有机化合物 (VOC) 显示出对非侵入性诊断阻塞性睡眠呼吸暂停 (OSA) 的希望. 乙化成为与OSA严重程度相关的关键生物标志物.
科学领域:
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
- 分析化学 分析化学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的睡眠障碍,具有严重的健康影响.
- 目前的诊断方法,如多睡眠学是资源密集型和耗时的.
- 需要非侵入性诊断方法来改善患者护理和可访问性.
研究的目的:
- 调查质子转移反应质谱法 (PTR-MS) 的潜力,以识别OSA.的挥发性有机化合物 (VOC) 生物标志物.
- 评估已识别的VOC生物标志物与OSA的严重程度之间的相关性,通过呼吸暂停-呼吸暂停指数 (AHI) 来衡量.
主要方法:
- 89名参与者的呼吸样本 (49名OSA患者,40名对照组) 用PTR-MS.进行了分析.
- 统计分析,包括威尔科克森等级总和测试和部分最小平方差异分析 (PLS-DA),用于识别差异化的VOC.
- 进行回归分析以将VOC水平与AHI相关联.
主要成果:
- 在OSA患者和对照者之间,特定的VOC,包括乙 (m045),m095.950和m097.071,有显著差异.
- PLS-DA和相关映射证实了这些VOC生物标志物的稳定性.
- 乙甲 (m045) 与AHI显著相关,表明其作为严重性生物标志物的潜力.
结论:
- 通过PTR-MS识别的VOC显示出潜在的非侵入性生物标志物,用于检测OSA并评估其严重程度.
- PTR-MS为OSA查提供了一种快速,具有成本效益的方法,可能有助于临床分层和优先考虑多睡眠学.
- 建议在更大的队列中进行进一步验证,并与其他诊断工具集成,以提高临床效用.
相关概念视频
01:21Sleep Apnea
125
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
125
01:24Substance Use Disorders Affecting Sleep
158
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
158
01:25Hyperpnea and Hyperventilation
970
Hyperventilation refers to a higher-than-normal rate and depth of breathing, often associated with anxiety attacks. This excessive breathing surpasses the body's need to expel CO2, leading to a condition known as hypocapnia - an unusually low level of carbon dioxide in the blood. Hypocapnia can constrict cerebral blood vessels, reducing blood flow to the brain, which may result in dizziness or fainting. Early signs include tingling and muscle spasms in the hands and face, caused by falling...
970
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:19Special considerations while measuring oxygen saturation
531
Assessing respiratory rate concurrently with pulse measurement is fundamental to patient care, providing valuable insights into the patient's respiratory function. The normal breathing rate for an adult usually falls within a normal range of 12 to 20 breaths per minute. Abnormal respiratory rates can signal underlying health conditions or the need for immediate intervention.
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is...
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is...
531
01:20Assessment of Ventilation I: Respiratory Rate
993
Assessment of Ventilation
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
993