循环聚硫 - 酸骨植入物的长期稳定性和骨质活性在体外
Chi-Nan Chang1, Yun-Ru Huang1, Shinn-Jyh Ding1,2,3
1Institute of Oral Science, Chung Shan Medical University, Taichung City 402, Taiwan.
Journal of functional biomaterials
|January 24, 2025
概括
回收的多硫 (PSF) 医疗废物被增强为酸 (CaSi) 用于骨植入物. 20%的CaSi-PSF复合物显示出有希望的骨质生成活性和负载应用的生物稳定性.
科学领域:
- 生物材料科学 生物材料科学
- 整形外科工程 整形外科工程
- 材料回收利用 材料回收利用
背景情况:
- 聚硫 (PSF) 是一种高性能塑料,有可能用于骨科植入物,但需要增强骨质生成.
- 长期的机械稳定性对于承载性骨植入物至关重要.
- 回收PSF医疗废物解决了环境问题和材料短缺问题.
研究的目的:
- 将多硫 (PSF) 医疗废物循环升级为骨复合材料,通过将骨性酸盐 (CaSi) 纳入.
- 评估用于骨科应用的PSF-CaSi复合材料的生物稳定性和骨质生成潜力.
主要方法:
- 在PSF医疗废物中,含有10%,20%和30%的酸 (CaSi).
- 复合材料被浸入模拟体液 (SBF) 中12个月,pH值为7.4和5.0.
- 评估了阶段,形态,体重减轻,曲强度和人类介质干细胞 (hMSC) 的骨质性活性.
主要成果:
- 在SBF中12个月后,PSF-CaSi复合材料表现出可控的体重减轻 (~4%).
- 曲强度随着长时间的SBF暴露而降低.
- 加入CaSi对hMSC的附着,扩散,性酸酶 (ALP) 水平和沉积产生了积极的影响,与CaSi含量相关.
结论:
- 20%的CaSi-PSF复合物显示出生物稳定性和骨质生成能力的良好平衡.
- 这种复合材料显示出作为承载性骨科植入物的候选材料的潜力.
- 使用CaSi再利用PSF医疗废物提供了一种可持续的方法来开发增强的骨植入物材料.
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