与大规模集会相关的抗菌素耐药性:系统性审查
Linda Tong Pao1, Mohamed Tashani2,3,4, Catherine King5,6
1Sydney Children's Hospitals Network, Westmead, NSW 2145, Australia.
参加大众集会,特别是宗教活动,与获得抗菌素耐药性 (AMR) 有关. 研究表明,在大型事件发生后,耐药性细菌增加,如大肠杆菌和肺炎.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 大众聚会被认为是传染性疾病传播的潜在热点.
- 新出现的证据表明,参加大规模集会与获得抗菌素耐药性 (AMR) 之间存在联系.
研究的目的:
- 系统地审查和综合现有证据,对大规模聚会出席和AMR之间的关联.
- 评估在群众聚会上常见的病原体中AMR的流行率.
主要方法:
- 在主要数据库 (Cochrane,Medline,Scopus,Embase) 进行了全面的文献搜索.
- 包括报告大规模集会和AMR结果的原始数据的研究.
- 由于研究异质性,进行了叙事综合,排除了元分析.
主要成果:
- 44项研究符合纳入标准,其中大多数研究集中在宗教大规模聚会上.
- 在朝后观察到抗生素耐药性大肠杆菌和克莱布西拉肺炎的显著增加.
- 报告了扩展谱β-乳糖酶 (ESBL) 或卡巴酶基因的提升载体和非敏感的Streptococcus pneumoniae分离物.
结论:
- 参加大众集会与获得特定的抗菌素耐药性表型和基因型有关.
- 诸如大肠杆菌 (E. coli) 和肺炎菌 (S. pneumoniae) 等病原体在治疗后表现出抗药性增加.
- 需要进一步的研究,以了解大规模集会中AMR传播的全部范围和影响.
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