TLR抗原免疫辅助剂在对PCV2和PRV的双等级子单位疫苗中提供有效的PCV2和PRV感染保护
Fulai Yu1,2, Wei Xiang2, Weiye Ou3
1Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
Veterinary sciences
|January 24, 2025
概括
一种新的双价子单元疫苗,结合了猪病毒2型 (PCV2) 和伪狂犬病病毒 (PRV),显示出有前途. 该疫苗,特别是具有新型辅助剂的疫苗,有效地保护猪免受PRV挑战,并减少PCV2病毒载量.
科学领域:
- 兽医病毒学 兽医病毒学
- 免疫学 免疫学 免疫学
- 疫苗开发 疫苗开发
背景情况:
- 猪圈病毒2型 (PCV2) 和伪狂犬病病毒 (PRV) 在养猪业造成了重大经济损失.
- 联合感染和二次细菌共感染加剧了疾病的影响.
研究的目的:
- 开发和评估一种针对PCV2和PRV的双价子单元疫苗.
- 评估一种含有模式识别受体 (PRR) 激动剂 (FLICd) 的新型微水凝辅助剂的疗效.
主要方法:
- 使用PCV2 Cap蛋白和PRV gB/gD蛋白制造了一种双价子单位疫苗.
- 猪接种了单独的双价疫苗或FLICd辅助剂.
- 疫苗接种后评估了抗体标位,体重增加和挑战测试 (PRV).
主要成果:
- 与对照组相比,接种疫苗的组显示出明显更高的PRV和PCV2抗体水平.
- 接受FLICd辅助剂的组表现出更高的PRV特异性中和抗体标位.
- 在接种疫苗的群体中,实现了对PRV挑战的100%保护,病毒载量和流失减少.
结论:
- 双价子单元疫苗有效地预防PCV2相关疾病和伪狂犬病病毒感染.
- 加入FLICd辅助剂可以增强对PRV的免疫反应.
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