食补充剂影响羊的皮肤附属物中的格林林系统表达
Margherita Maranesi1, Cecilia Dall'Aglio1, Sara Moscatelli2,3
1Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy.
Veterinary sciences
|January 24, 2025
概括
格林素 (GhRL) 影响皮肤的修复. 这项研究发现羊皮的附属物中存在林系统,饮食会影响其在毛囊和汗腺中的表达.
科学领域:
- 兽医皮肤病学 兽医皮肤病学
- 内分泌学 在内分泌学.
- 动物营养 动物营养
背景情况:
- 格林 (GhRL) 是一种氧化激素,影响营养状况,在皮肤修复和疾病中起作用.
- 关于皮肤内的 ghrelin 系统功能的信息有限.
- 这项研究研究了在不同饮食条件下羊皮中的 ghrelin 和它的受体.
研究的目的:
- 为了研究羊皮的 ghrelin 系统的存在和局部.
- 探索不同的养条件和食补充剂如何影响皮肤中的 ghrelin 系统表达.
主要方法:
- 在不同的放牧和补充方案下,从动物身上采集了绵羊皮样本.
- 免疫组织化学被用来可视化格林及其受体在皮肤附属部分的定位.
- 实时PCR量化了ghrelin及其受体的基因表达水平.
主要成果:
- 格林系统 (连接体和受体) 在羊皮的附属物中被确定,包括毛囊和汗腺.
- 在接受食补充剂 (Exp组) 的羊群中,与没有 (MxF组) 的羊群相比,格林素及其受体的基因表达显著更高.
- 格林林连接体局部化在毛囊中,而受体在毛囊,汗腺和光滑肌肉细胞中被发现.
结论:
- 林系统存在于绵羊皮肤中并具有功能,特别是在毛囊和汗腺中.
- 食补充剂似乎可以积极调节羊皮中的 ghrelin 和其受体的表达.
- 皮肤中的格雷林系统活性可能受到营养状况的影响,并在皮肤附属体调节中发挥作用.
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