系统冠状动脉风险评估2 (SCORE2),动脉硬和亚临床冠状动脉样硬化在基于人口的研究中
Susanna Strömberg1, Andreas Stomby1,2, Jan Engvall3
1Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Scandinavian journal of primary health care
|January 24, 2025
概括
根据系统冠状动脉风险评估2 (SCORE2) 工具的评估,高心血管风险与没有现有心脏病或糖尿病的个体的动脉硬和冠状动脉化增加有关.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 公共卫生 公共卫生
背景情况:
- 诸如SCORE2之类的心血管风险评估工具对于识别心脏病风险较高的个体至关重要.
- 冠状动脉和大动脉的亚临床血管损伤可以在临床事件之前发生.
- 了解风险得分与亚临床损害之间的关联对于初级预防至关重要.
研究的目的:
- 检查系统冠状动脉风险评估2 (SCORE2) 风险类别和亚临床动脉样硬化 (冠状动脉分数 - CACS) 和大动脉动脉硬度 (脉冲波速度 - PWV) 之间的关系.
- 为了评估这些协会在一个庞大的,基于人口的群体中,没有普遍的心血管疾病和糖尿病.
主要方法:
- 这是一项采用瑞典心脏肺部生物成像研究 (SCAPIS) 数据的横截面研究.
- 包括3087名50-64岁的参与者,没有心血管疾病或糖尿病.
- 测量PWV用于动脉硬 (定义为PWV ≥10m/s) 和CACS用于冠状动脉化 (定义为CACS>100).
主要成果:
- 动脉硬的患病率与SCORE2风险增加:6.6% (低至中等),31.0% (高),53.3% (非常高).
- 冠状动脉化的患病率也增加了:4.5% (低至中等),18.5% (高) 和23.0% (非常高).
- 与中低风险相比,高的SCORE2风险与动脉硬性 (OR 6.4) 和冠状动脉化 (OR 4.8) 有显著的关联.
结论:
- 在无症状人群中,SCORE2风险升高与亚临床动脉硬性和冠状动脉化密切相关.
- 这些发现支持SCORE2在初级保健中的实用性,用于识别潜在血管损伤的个体.
- 动脉硬和冠状动脉化似乎代表了血管损伤的不同方面,尽管它们与整体心血管风险有关.
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