在Covid-19中进入血管内皮的窗口:指甲
Ozge Sevil Karstarli Bakay1, Niyazi Cetin1, Umut Bakay2
1Pamukkale University Faculty of Medicine, Department of Dermatology, Denizli, Turkey.
Dermatology practical & conceptual
|January 24, 2025
概括
皮肤透视显示了COVID-19患者指甲的显著微血管变化,包括无血管区域和曲的毛细血管. 这些指甲床异常随着时间的推移而回归,这表明监测COVID-19恢复的潜力.
科学领域:
- 血管生物学 血管生物学
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- 内皮损伤是COVID-19并发症的一个关键因素.
- 靠近指甲折叠毛细血管提供了对微血管功能障碍的见解.
研究的目的:
- 用皮肤镜检查COVID-19患者的微血管变化.
- 在2019年冠状病毒病 (COVID-19) 患者中检查近接指甲毛细血管和指甲床.
主要方法:
- 展望性研究比较轻度至中度COVID-19患者和健康对照组.
- 皮肤镜检查靠近的指甲毛细血管和指甲床.
- 症状出现后两周进行初步评估,10-14个月后进行随访.
主要成果:
- 在COVID-19患者中,无血管区域,曲的毛细血管,微型出血和毛细血管膨胀的患病率较高.
- 在COVID-19患者中观察到无组织的毛细管架构和减少的密度.
- 随访显示微血管变化的回归.
结论:
- 靠近指甲折叠皮肤镜是观察COVID-19相关的微血管变化的宝贵工具.
- 这种方法具有成本效益,并且很容易获得临床使用.
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