部杂交的牙致癌瘤是什么
Fernanda Brasil Daura Jorge Boos-Lima1,2, Talita de Carvalho Kimura3, Flávia Akemi Nakayama Henschel3
1Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA. fernandabooslima@gmail.com.
Oral and maxillofacial surgery
|January 24, 2025
概括
这份病例报告详细介绍了第一个下混合牙致癌瘤 (HOT),其中包括乳腺母细胞瘤,结石化表皮性牙致癌瘤和乳腺母细胞纤维瘤. 早期诊断和全面的手术管理对于这些罕见的复杂病变的良好结果至关重要.
科学领域:
- 口腔和牙面部外科手术
- 病理学 病理学 病理学
- 在瘤学瘤学.
背景情况:
- 混合牙性瘤 (HOT) 的特点是两个或两个以上不同的牙性瘤类型在同一口面部区域内共存.
- 这些复杂的病变存在诊断和治疗方面的挑战,因为它们的稀有性和各种组织学成分.
研究的目的:
- 报告第一个 mandibular 杂交 odontogenic 瘤 (HOT) 病例,涉及乳腺母细胞瘤,结石化表皮性乳腺母细胞瘤和乳腺母细胞纤维瘤.
- 突出这种罕见的复杂牙病理的诊断考虑和手术管理.
主要方法:
- 描述了一个37岁的男性下下胀的综合性临床表现.
- 诊断成像包括计算机断层扫描 (CT) 来界定骨解质,多局部和扩张性病变.
- 通过1厘米的安全边缘进行口内切除手术,然后进行微血管化骨片重建.
主要成果:
- 该患者出现了大,扩张的下病变,涉及多种口腔瘤类型.
- 取得了成功的手术切除和重建.
- 十年的随访证实,混合型牙致癌瘤没有复发.
结论:
- 混合性牙致病性瘤虽然很少见,但必须在广泛的牙致病性病理的差异诊断中考虑.
- 由于显微镜的变异性,通过多次活检进行彻底的组织病理学检查对于准确的诊断至关重要.
- 了解病原和病理生理学是改善HOT患者治疗策略和手术结果的关键.
相关概念视频
Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Teeth
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...


